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The correct answer indicates that once opened, eye drops should have a beyond-use date (BUD) of not later than 1 month. This guideline is based on stability studies that determine how long a sterile product maintains its efficacy and safety after opening. When eye drops are opened, their sterility can be compromised due to exposure to environmental factors such as air, light, and potential contamination from the applicator tip.

However, research and regulations often suggest that for liquid formulations like eye drops, if they are stored properly (for instance, in a cool, dark place), they are typically stable for up to 30 days after opening. This duration helps ensure the patient can use the product safely without significant risk of degradation or contamination.

The other choices represent time frames that do not align with the established BUD for opened eye drops. A shorter duration of 14 days, 1 month, or 1 week lacks the balance of safety and practicality that one month provides while also considering the needs of patients using the product.